Detection of acute myocardial infarct with T1-mapping post ferumoxytol contrast administration

نویسندگان

  • Deneen Spatz
  • Igor Klem
  • Lowie M Van Assche
  • Enn-Ling Chen
  • Wolfgang G Rehwald
  • Han W Kim
  • Christoph J Jensen
  • David Wendell
  • Elizabeth Jenista
  • Raymond J Kim
چکیده

Background Gadolinium-enhanced CMR can be a useful adjunct in the diagnosis and assessment of acute myocardial infarction (AMI). However, gadolinium contrast is contraindicated in severe renal impairment. Alternative, non-gadolinium contrast agents for AMI assessment and contrast-enhanced CMR in general would be of substantial clinical importance. Ferumoxytol, an intravenous iron-supplementation drug, was approved in 2009 by the FDA for treatment of iron-deficiency anemia in patients with chronic kidney disease, and is known to have T1 shortening properties. The utility of T1-weighted ferumoxytol-enhanced CMR for detecting AMI has not been previously evaluated.

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عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2013